As shown in Figure 5, the vacuolation observed by TEM is generally consistent with the pathological findings. As the dose increased, the vacuoles in CP epithelial cells were enlarged, more prevalent, and more likely to contain electron compacts, which manifest as dense black dots (denoted in Figure 5 with arrows). These electron compacts are consistent with PEG deposits, as the location and shape of the compacts correlate with the pattern of anti-PEG IHC staining rein the CP.
Meta description - Meta descriptions are displayed in the search results, are known to impact Endbenutzer behavior and hinein some cases can Beryllium rewritten by Google. Include a unique meta description for each page and don’t forget to include your target keywords.
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A functional observational battery (FOB) of neurobehavioral assessments was conducted to detect any neurobehavioral deficits resulting from potential CP dysfunction, including home cage observations, out-of-cage observations, and open field activity assessments rein animals of both control and animals treated with 0.
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Most pegylated pharmaceuticals induce vacuolation in animal tissues and macrophages rein nonclinical studies due to PEG accumulation. Currently, although the accumulation of PEG rein the choroid plexus epithelium of animals administered repeat-doses of PEGylated products appears to Beryllium an adaptive, non-adverse finding (41) based on the lack of any signs of tissue degeneration or dysfunction, safety concerns about the PEG accumulation (28) and PEG-induced vacuolation persisted due to the lack of extensive investigation and data on the impact on tissue function, particularly in the CP tissue function and epithelial cellular structure by EMT, etc.
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